Familial hypercholesterolaemia is an inherited condition which leads to high cholesterol levels. Find out how you can get tested and what are the treatments available. High Cholesterol (Hypercholesterolaemia) A high blood cholesterol level means that you have more cholesterol in your bloodstream than your body can use. Read about the possible causes of high cholesterol, including having an unhealthy diet, lack of exercise, being overweight, smoking, and drinking too much alcohol. Find patient medical information for GUGGUL on WebMD including its uses, effectiveness, side effects and safety, interactions, user ratings and products that have it. ![]() ![]() ![]() ![]() High blood pressure (hypertension) occurs when blood is forced through the arteries at an increased pressure. Get expert advice on symptoms, possible complications. An error occurred while setting your user cookie. Please set your. browser to accept cookies to continue. This cookie stores just a. ID; no other information is captured. Accepting the NEJM cookie is. GUGGUL: Uses, Side Effects, Interactions and Warnings. References: Antonio J, Colker CM, Torina GC, and et al. Effects of a standardized guggulsterone phosphate supplement on body composition in overweight adults: A pilot study. Curr Ther Res 1. 99. ![]() B., Kapoor, V., Gupta, S. Isolation of a crystalline steroidal compound from Commiphora mukul & its anti- inflammatory activity. Indian J Exp Biol 1. B., Taneja, V., Sharma, R. Anti- inflammatory studies on a crystalline steroid isolated from Commiphora mukul. Indian J Med Res 1. Drugs Fut 1. 98. 8; 1. H and 1. 3C assignments of five cembrenes from guggul. Baldwa VS, Sharma RC, Ranka PC, and et al. Effect of Commiphora mukul (guggul) on fibrinolytic activity and platelet aggregation in coronary artery disease. Rajas Med J 1. 98. A study of effect of guggulsterone on hyperlipidemia of secondary glomerulopathy. Indian J Physiol Pharmacol 1. Conceptual and methodologic challenges of assessing the short- term efficacy of Guggulu in obesity: data emergent from a naturalistic clinical trial. J Postgrad. Med 1. Effect of gum guggulu on fibrinolysis and platelet adhesiveness in coronary heart disease. Indian J Med Res 1. P., Montrose, C., Houck, K. D., Krishnan, V., Bullock, H. J., Bramlett, K., and Stayrook, K. The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand. ![]() ![]() Familial hypercholesterolemia is an inherited condition that causes high levels of LDL (low density lipoprotein) cholesterol levels beginning at birth, and heart. 2015-02-2 Last revised in October 2015 Back to top Hypercholesterolaemia - familial - Summary. Familial hypercholesterolaemia (FH) is characterized by a high. The renal diet is an essential part of treatment – it helps you to feel well and avoids complications like fluid overload, high blood potassium, itching, bone. Just what I had thought, so pleased that I am normal, all my bloods are normal, I eat a healthy diet and took myself off statins, my cholesterol was 7.8. Achieving blemish-free, glowing skin may seem like a daunting task, but the solution may be no further than your kitchen. These 26 meals are packed with. ![]() ![]() H., Sassano, G., Rawlins, C., Mayes, A. N., O'Dowd, J., Stocker, C., Wargent, E., Cawthorne, M. Identification of a novel agonist of peroxisome proliferator- activated receptors alpha and gamma that may contribute to the anti- diabetic activity of guggulipid in Lep(ob)/Lep(ob) mice. Cui, J., Huang, L., Zhao, A., Lew, J. L., Yu, J., Sahoo, S., Meinke, P. T., Royo, I., Pelaez, F., and Wright, S. Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump. Gugulipid: pro- lipaemic effect. J Assoc Physicians India 1. Pro- lipidaemic effect. Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits. Ethnotherapeutics and modern drug development: the potential of Ayurveda. Curr Sci 1. 99. 7; 7. Dogra J, Aneja N, and Saxena VN. Oral gugulipid in acne vulgaris management. Ind J Dermatol Venereol Leprol 1. Duwiejua, M., Zeitlin, I. G., Chapman, J., Mhango, G. Anti- inflammatory activity of resins from some species of the plant family Burseraceae. Planta Med 1. 99. Bioactive terpenoids and guggulusteroids from Commiphora mukul gum resin of potential anti- inflammatory interest. Gaur SP, Garg RK, Kar AM, and et al. Gugulipid, a new hypolipidaemic agent, in patients of acute ischaemic stroke: effect on clinical outcome, platelet function and serum lipids. Asia Pacif J Pharm 1. Adverse cutaneous reactions to guggulipid. Pt 1): 5. 33- 5. 34. Ghorai, M., Mandal, S. A comparative study on hypocholesterolaemic effect of allicin, whole germinated seeds of bengal gram and guggulipid of gum gugglu. Phytother. Res 2. K., Nityanand, S., Gupta, P. P., Hasan, M., Das, S. K., Sinha, N., and Agarwal, S. Clinical trial of ethyl acetate extract of gum gugulu (gugulipid) in primary hyperlipidemia. J Assoc Physicians India 1. Gujral ML, Sareen K, Reddy GS, and et al. Endocrinological studies on the oleo resin of gum guggul. Indian J Med Sci 1. Hasani- Ranjbar, S., Nayebi, N., Moradi, L., Mehri, A., Larijani, B., and Abdollahi, M. The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review. Curr. Pharm. Des 2. Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor- kappa. B ligand and by tumor cells by suppressing nuclear factor- kappa. B activation. 1- 1. Clinical assessment of the value of oleo- resin of Commiphora mukul (Guggul) in obesity and hyperlipidemia. ICMR Bull 1. 98. 0; 1. Reversal of changes of lipid peroxide, xanthine oxidase and superoxide dismutase by cardio- protective drugs in isoproterenol induced myocardial necrosis in rats. Indian J Exp Biol 1. Effect of a new non- steroidal anti- inflammatory agent on lysosomal stability in adjuvant induced arthritis. Ital J Biochem 1. Kesava, Reddy G., Dhar, S. Urinary excretion of connective tissue metabolites under the influence of a new non- steroidal anti- inflammatory agent in adjuvant induced arthritis. Agents Actions 1. Khanna, D., Sethi, G., Ahn, K. B., Sung, B., Aggarwal, A., and Aggarwal, B. Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol 2. Kishore P, Devi Das KV, and Banarjee S. Clinical studies on the treatment of Amavata- Rheumatoid arthritis with Sunthi- Guggulu. J Res Ayur Siddha 1. Kolonte, A., Guillot, B., and Raison- Peyron, N. Allergic contact dermatitis to guggul extract contained in an anticellulite gel- cream. Contact Dermatitis 2. Kotiyal JP, Bisht DB, and Singh DS. Double blind cross- over trial of gum guggulu (Commiphora mukul) Fraction A in hypercholesterolemia. J Res Indian Med Yoga Hom 1. Kotiyal JP, Singh DS, and Bisht DB. Gum guggulu (Commiphora mukul) fraction 'A' in obesity - - a double- blind clinical trial. J Res Ayur and Siddha 1. Double blind cross over trial of C. Fraction A) in hypercholesterolaemia and obesity. J Res Ayur Siddha 1. Kuppurajan K, Rajagopalan SS, Koteswara Rao T, and et al. Effect of guggulu (Commiphora mukul- Engl) on serum lipids in obese subjects. J Res Indian Med 1. Kuppurajan, K., Rajagopalan, S. Effect of guggulu (Commiphora mukul- -Engl.) on serum lipids in obese, hypercholesterolemic and hyperlipemic cases. J Assoc Physicians India 1. Mahesh S, Pandit M, and Hakala C. A study of Shuddha Guggulu on rheumatoid arthritis. Rheumatism 1. 98. A clinical study of R- Arthritis with A- Compound - a herbal formulation. Rheumatism 1. 98. Role of gum guggulu with gold in rheumatic and other allied disorders. Rheumatism 1. 98. Comparative hypolipidaemic effectiveness of gum guggulu (Commiphora mukul) fraction 'A', ethyl- P- chlorophenoxyisobutyrate and Ciba- 1. Su. Indian J Med Res 1. Manjula, N., Gayathri, B., Vinaykumar, K. S., Shankernarayanan, N. A., and Balakrishnan, A. Inhibition of MAP kinases by crude extract and pure compound isolated from Commiphora mukul leads to down regulation of TNF- alpha, IL- 1beta and IL- 2. The effects of various fractions of gum guggul on experimentally produced hypercholestraemia in chicks. Indian J Physiol Pharmacol 1. Mester, L., Mester, M., and Nityanand, S. Inhibition of platelet aggregation by . Planta Med 1. 97. Botanical influences on cardiovascular disease. Complementary and alternative therapies for the management of dyslipidemia. Ann Pharmacother 2. Cholesterol lowering activity of the various fractions of the guggal. Indian J Exp Biol 1. Hypocholesterolemic effect of Commiphora mukul resin (guggal). Indian J Exp Biol 1. Guggulipid supplements for high cholesterol questionable. Mayo Clin. Health Lett. Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Posadzki, P., Watson, L. Adverse effects of herbal medicines: an overview of systematic reviews. Clin Med 2. 01. 3; 1. Rahimi, R., Shams- Ardekani, M. A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. World J Gastroenterol. Antibacterial activities of some constituents from oleo- gum- resin of Commiphora mukul. Fitoterapia 2. 00. Sahni, S., Hepfinger, C. Guggulipid use in hyperlipidemia: case report and review of the literature. Am. J. Health Syst. Pharm. 8- 1. 5- 2. Salavert, M., Amarger, S., Le Bouedec, M. C., Roger, H., Souteyrand, P., and D'incan, M. Allergic contact dermatitis to guggul in a slimming cream. Contact Dermatitis 2. Gum guggul (Commiphora mukul)- -the success story of an ancient insight leading to a modern discovery. Indian J Med Res 1. P., Pal, R., Singh, S., Pratap, R., and Nath, C. Gugulipid, an extract of Commiphora whighitii with lipid- lowering properties, has protective effects against streptozotocin- induced memory deficits in mice. Pharmacol. Biochem. Behav. Shah, R., Gulati, V., and Palombo, E. Pharmacological properties of guggulsterones, the major active components of gum guggul. Sharma K, Puri AS, Sharma R, and et al. Effect of gum guggul on serum lipids in obese subjects. J Res Indian Med Yoga Hom 1. Comparison of the anti- inflammatory activity of Commiphora mukul (an indigenous drug) with those of phenylbutazone and ibuprofen in experimental arthritis induced by mycobacterial adjuvant. Arzneimittelforschung 1. Effects of S- allyl cysteine sulfoxide isolated from Allium sativum Linn and gugulipid on some enzymes and fecal excretions of bile acids and sterols in cholesterol fed rats. Indian J Exp Biol 1. Guggul for hypercholesterolemia. Am. J. Health Syst. Pharm. 5- 1. 5- 2. Shishodia, S., Harikumar, K. B., Dass, S., Ramawat, K. The guggul for chronic diseases: ancient medicine, modern targets. A): 3. 64. 7- 3. 66. Shishodia, S., Sethi, G., Ahn, K. Guggulsterone inhibits tumor cell proliferation, induces S- phase arrest, and promotes apoptosis through activation of c- Jun N- terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. Sidhu LS, Sharma K, Puri AS, and et al. Effect of gum guggul on body weight and subcutaneous tissue folds. J Res Indian Med Yoga Hom 1. Singh K, Chander R, and Kapoor NK. Guggulsterone, a potent hypolipidaemic, prevents oxidation of low density lipoprotein. Phytother Res 1. 99. Singh RP, Singh R, Ram P, and et al. Use of Pushkar- Guggul, an indigenous antiischemic combination, in the management of ischemic heart disease. Int J Pharmacog 1. P., Aquilina, N., Singh, V. The effectiveness of Commiphora mukul for osteoarthritis of the knee: an outcomes study. Altern. Ther. Health Med. P., Der- Martirosian, C., Kubik, E., Mishra, L. J., Meier, M., and Madhu, S. Ayurvedic and collateral herbal treatments for hyperlipidemia: a systematic review of randomized controlled trials and quasi- experimental designs. Altern. Ther Health Med 2. Pharmacology of an extract of salai guggal ex- Boswellia serrata, a new non- steroidal anti- inflammatory agent. Agents Actions 1.
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